A new species, Anthrenus (Nathrenus) turneri Holloway (Coleoptera: Dermestidae: Megatominae), is described from South Africa and compared with other Nathrenus Casey, 1900 species from the same region. South African Nathrenus species are understudied, but of the known species, many could be eliminated as confounding species based on color pattern. The new species is compared with A. boyesi Hava, 2004 and A. margarethae Hava and Kadej, 2006, both South African species. Images of genitalia, antenna, and habitus arepresented. Anthrenus turneri represents the fifteenth Nathrenus species described from South Africa.